UPNEEQ Eye Drops 30 ctMeet Upneeq (oxymetazoline hydrochloride ophthalmic solution), 0. 1%, the first and only FDA approved prescription eye drop for adults with low lying lids (also known as acquired blepharoptosis or ptosis). It provides a non surgical eye lift, quickly lifting eyelids for more awake looking eyes. Just one drop per eye, once daily, is clinically proven to give visible results lifted and open eyelids in as fast as 5 minutes that can last up to 8 hours.